Abstract: Considering running safety of Karamay-Dushanzi Crude Oil Pipeline III(KDIII), the performances of pour point depressant(PPD)KD-1 for North Xinjiang #0 oil(NJ0), Lushi mixed oil(LM)and Chepaizi oil(CPZ)have been tested under different treatment temperature and dose contents. The results show that performance of this PPD is pretty good, stable and wide-adaptable. The PPD has been added in the pipeline KDIII and KD #377 as field experiments, and the results show that the pour point of the mixed oil of LM sheared by pump and CPZ have re-risen so much, which cannot meet the running demands of shutting down the 4th and 6th station HTM heater, but can meet the demands of the main station to 4th station section only. It is feasible and reasonable to add KD-1 in KDIII in economy and technology, and more than 200×104 RMB/yr will be saved. The usage of metering pump is summarized. It is also found that the temperature's pickup during sampling and testing has an effect on the PPD performance. And all of these are important for actual running of pipeline.