Abstract: Based on an optimization model against injection-production dynamic simulation of natural gas underground storage in depleted gas reserve, taken a minimum value of average stratum pressure change in the storage as an objective function in the case of meeting the requirement of city peak volume and pressure limit for each well head inside the storage, distributes optimum injection-production amount for each well scientifically and provides a theoretical basis for optimum operation of injection-production in dynamic state of natural gas underground storage. Gives a calculation example and analyzes the result calculated.