Abstract: The reliability of main pipeline is a comprehensive attribute consisted of several individual attributes, including fail-safety, maintainability, durability, controllability, lifetime and safety. To a great extent, the operating reliability of the main pipeline depends on the external conditions: on the one hand, it is the impact of physical environment, and on the other hand, it is the operating capability of production and processing systems of oil and gas, and the transportation enterprises should also meet the requirements of users. The authors consider that situations must be comprehensively analyzed in designing the main pipeline, that is, the study of pipeline should not only be made upon itself, but also made on the impact of interrelated technologies on the pipeline. The transfer capacity of the main pipeline, the reliability indexes of power equipments as well as the maintenance parameters are the prediction information of the reliability indexes in actual design. Still further, the analysis of oil pump station (compressor station), the specification and model of transfer equipment and the concrete connection way of transfer equipment have to be considered while the prediction information aforementioned are quantified to the specific design, and the concrete-ness and the accuracy of reliability indexes should be made for the equipments in each station if necessary. The calculations on the transfer capacity of pipeline and the several parameters have been made based on the current reliability indexes of the design adopted in Russia.