Abstract: Based on cared analysis of the present condition of the old Ke-Du Pipeline, cleaning requirements marked investigation results, considering the real operation status and various kinds of restrained conditions, experiment and research work are done on cleaning method selection.Among the methods, the one with chemical cleaning solution which is oil soluble can satisfy the requirements for the old Ke-Du Pipeline cleaning.The cleaning procedures are introduced as well.Comprehensive evaluation is performed on the economic benefits.Mean while, the writers point out the existing problems in cleaning and measures to solve them and hold the viewpoint that this method can also suit other pipeline cleaning.