Abstract: An introduction about Qin-Jing Pipeline is given in the paper with the layout of the pumping sets. The writer points out that Qin-Jing Pipeline renovation should start from process improvement, increase pump performance as well as hydraulic operation efficiency, etc.The general principle of optimized combination is given based on the performance of each pump unit.A. Prioty should be given to the pumps of high efficiencyB.Speed regulating equipment should be made the most use ofC.DKS pumps should be regulated with imported regulating valvesThree operation methods are given of the optimized combination of pumping sets of Qin-Jing Pipeline.For each operation method, analysis is performed on the number of the pumps in operation (the whole line) daily flowrate and unit power consumption. It is pointed out that there is direct relation between flowrate and the equivalent diameter of the pipeline. Therefore operation mode selection should be based on the equivalent diameter.