Abstract: Based on multi-objective decision-making optimization technique, the theory research on gas pipeline network operation optimization is carried out. System structure of large-scale gas pipeline network is made, basic principles and specific steps in setting up a comprehensive evaluation index system are given, standard modes in assessing analog operation scheme are put forward and the revaluation with compatibility degree on assessment method are recommended to use.Taking the pipeline networks of the first and second West-to-East Gas Transmission Pipelines and the JiNing Pipeline as an example, 5 sets of pipeline network operation schemes are structured, and the scheme determination with the multi-objective decision-making optimization technique for large-scale natural gas pipeline network is carried out.The results show that the ideas and methods are scientific and feasible, in which the fuzzy comprehensive evaluation method is most suitable for the established evaluation system.