Abstract: Taking the lowest power cost of pipeline system as an objective function, throughput of pump station as an constraint condition, including the constraint conditions in hydraulics, technology and pipe strength of pipeline etc., the authors set up a mathematical model for the optimization process and program computer procedure to realize the disposal and calculation on performance parameters of pump, that is, rational station span should be determined, speed governing pump is discretized as constant speed pump with different rotational speed to ascertain the pump running scenario of pump stations of the whole pipeline. Taking the pump stations in Southwest Products Pipeline as an example, in the case of N=300, G=300, P_c=0.25, P_m=0.03, genetic algorithm is used to do the optimized calculation in pump station number. The optimized pump opening scenario shows that power cost can be saved up to RMB 30.7×10⁴ RMB Yuan. The genetic algorithm can be adopted in the optimization model for the as-built pump station equipped with speed-regulating pumps of normal temperature oil pipeline, and then the best economic running scheduling scenario of pump station can be obtained.