Abstract: 【Objective】 The transportation of hydrogen-doped natural gas is one of the ways of large-scale hydrogen transportation, and the separation and purification of hydrogen is directly related to the quality and economic benefits of end-use hydrogen. Due to the low hydrogen content, complex composition, wide pressure range, and quality requirements of hydrogen and natural gas after separation, traditional separation and purification technologies are facing challenges such as low separation efficiency, high energy consumption, and insufficient adaptability. 【Methods】 Through literature research, the research progress of hydrogen separation and purification technology of hydrogen-doped natural gas was systematically reviewed, the characteristics and separation and purification requirements of hydrogen-doped natural gas were summarized, the development and characteristics of pressure swing adsorption, membrane separation, electrochemical hydrogen pump and integration technology were analyzed, and the key research directions of practical application were prospected. 【Results】 Under the constraints of economic benefits, pressure swing adsorption is faced with the problems of insufficient performance and natural gas recompression, so it is necessary to develop high-efficiency and low-cost adsorbents and optimize processes, and explore the direct adsorption and adsorption heat utilization paths of hydrogen. The membrane separation technology has a simple process, high recovery rate and strong scalability, and the improvement of its performance, life and cost will effectively promote the application of hydrogen separation and purification of hydrogen-doped natural gas. Electrochemical hydrogen pumps have shown integration potential due to the advantages of high efficiency and synchronous compression, but there are problems such as high energy cost, difficult hydrothermal management, and impurity poisoning, so it is necessary to improve the conductivity of proton membranes and anti-impurity permeability, develop toxic resistant catalysts, and optimize flow field and hydrothermal control strategies in the future. and further reduce equipment costs; The integrated technology takes into account the purity, recovery rate and cost, and is the most compatible with the hydrogen separation and purification of hydrogen-doped natural gas. 【Conclusion】 At present, the research on hydrogen separation and purification technology in hydrogen-blended natural gas is mostly concentrated in the theoretical research and experimental stage, and it is necessary to carry out practical tests on natural gas hydrogen blending platforms or projects as soon as possible, promote process optimization and equipment development in combination with real scenarios, improve technical economy, maturity and adaptability, and help the large-scale application of hydrogen energy.