Abstract: A domestic cloud simulation software platform named CloudLPS (Cloud-Based Liquid Pipeline Simulator) with complete independent intellectual property rights is developed, aiming to eliminate the long-term reliance on foreign commercial simulation softwares for liquid pipeline simulation. The platform is built on a B/S cloud architecture and is designed with the goals of accuracy, speed, simple interfaces, and convenient interaction. In terms of models, in addition to conventional flow and heat transfer models, CloudLPS also introduces the advanced mathematical models such as the non-Newtonian fluid model and the cross-dimensional thermal model, which enables the software to have the capability of hydraulic and thermal simulations for condensable and high-viscosity crude oil pipelines. Furthermore, the software also introduces some efficient simulation methods, such as adaptive mesh, dynamic mesh, divide and conquer, and heterogeneous parallelization, to facilitate the rapid calculation of large and complex pipe network system. In terms of functionality, it primarily offers users a variety of business and composite business function support to crude oil and refined oil pipeline networks, such as steady-state and unsteady-state simulations of pipeline network system, logic control, water hammer analysis, batch tracking, shutdown and restart, energy consumption optimization, and more. Additionally, the software provides a user-friendly visual modeling and result data display and analysis environment. CloudLPS serves as a fundamental software tool that plays a supportive role in various aspects of pipeline network system, such as planning and designing, operation scheduling, risk decision-making, and other business scenarios. Its application holds significant importance in ensuring the safe and economic operation of liquid pipelines in China.