Abstract: Severe pipeline vibration will affect the safe operation of hydrogen compressor equipment. In terms of the violent vibration of the primary gas intake pipeline of a variable operating conditions hydrogen compressor with a 60% gas load, the gas flow pulsation and vibration of the primary gas intake pipeline were tested under 40%~100% gas load conditions. Also, gas flow pulsation analysis and pipeline modal analysis were carried out by modeling according to the actual pipeline size and routing. Based on the test and simulation results, it was concluded that the violent vibration of the primary gas intake pipeline was caused by the mechanical resonance at the pipeline point with second-order natural frequency. Meanwhile, the targeted pipeline vibration reduction measures were put forward to reduce the vibration value of the primary intake pipeline of the compressor to an acceptable range. The vibration causes analysis and control method are of great guiding significance for the design, operation and vibration monitoring of the pipeline system of hydrogen compressor under variable working conditions.