Abstract: Aiming at the problems of untimely manual flow path switching under abnormal working conditions and long time required for pressure regulation through the PID control of the regulating valves of A-Du-Wu-Shan system, risk analysis was carried out for the two operation modes after transformation, appropriate risk prevention measures were developed, and the superiority of PID control of the regulating valves was clarified. Thereby, the PID parameters of the regulating valves in Urumqi Station were reset with the engineering tuning method, the reliability and the rapid disposal ability of the PID control of the regulating valves were verified by differential pressure test and emergency condition simulation, and the influencing factors of the PID control effect were analyzed. The results show that, the reset PID parameters of Urumqi Station can achieve the fast and accurate automatic control of the inlet regulating valves under flow path switching and emergency conditions, and the pressure regulation time decreases from 780 seconds to about 75 seconds with small oscillation. Generally, the research results could provide guidance for the accurate control and abnormal condition treatment regulating valves, and lay a theoretical foundation for the realization of intelligent control of pipelines.