Abstract: At present, mileage is used as the location datum of pipeline defects, anomalies and feature points, which is not conducive to defect repair and deep utilization of in-line inspection data. Therefore, the technical process of coordinated in-line inspection data by center line measurement is put forward to solve this problem. The mathematical algorithm model of calculating pipeline length, elbow direction and curvature radius by center line measurement is established, the alignment fitting method of center line and in-line inspection feature points is studied and established, and the selection principle of fitting points is established. The excavation test shows that the average deviation of the technology is 0.37 m, and it is confirmed that the method is effective. Through the coordinated work of in-line inspection data, the workload and cost of repairing can be reduced, the cause, development trend and corrosion activity of pipeline defects can be analyzed in depth by aligning with external inspection data of pipeline, providing technical support for integration of pipeline data.