Abstract: In the actual construction of Central Asia-China Gas Pipeline, 8 cross-over lines were set up for Line C in Kazakhstan, achieving the interconnection between Lines AB and C. Meanwhile, 8 reserved points were provided along Line C in Uzbekistan. With the experience of the joint operation in Kazakhstan section, the comprehensive capacity of the whole system can be further improved if cross-over lines are added at appropriate positions in the Uzbekistan section. For this purpose, a simulation model was established for the joint operation of the Lines AB/C of Central Asia–China Gas Pipeline, the optimal distribution principle of Lines AB and C under different total throughput was determined, and the effect of operation with cross-over lines added at the 8 reserved points in Uzbekistan section was estimated respectively. Additionally, comparison was made for the throughput increasing schemes of the system with cross-over lines by assuming that the emergency shutdown occurred at the gas resources of Turkmenistan and Uzbekistan, and finally, it was determined to add cross-over lines at 4 reserved points in Uzbekistan. Hence, the research results could provide reference for the practical engineering reformation and the subsequent production.