Abstract: Intelligent operation is the core business of the intelligent pipeline network system, and the assistant decision system is the backbone supporting the intelligent operation of pipeline. Based on the top-level design and overall framework of the former PetroChina Pipeline Co. Ltd. for intelligent pipeline network, the intelligent operation and development scheme was piloted on China-Myanmar Crude Oil Pipeline based on its characteristics of large terrain undulation, complex geological conditions and the sensitive surrounding environment. By analyzing the construction framework and practice of intelligent pipeline of the former PetroChina Pipeline Co. Ltd. and foreign countries, the development scheme of assistant decision system, comprising operation management, safety control and full life cycle integrity management, was put forward based on the building of IoT sharing system, digital restoration system and cloud data center. Definitely, the development difficulties were analyzed and the technical route of overall planning and step-by-step implementation was discussed, to achieve the connotation goals of the intelligent operation of pipeline including real-time autonomous optimization of pipeline operation management, controllable safety prediction and early warning, and high intelligence of full life cycle integrity management.