Abstract: Natural gas venting will have a significant impact on the gas sources and users, and great safety risks may exist in engineering practice. Therefore, gas venting is one of the important tasks in the maintenance and construction of the gas pipeline. Determining the key parameters of venting with scientific tools based on the actual conditions of gas pipelines and requirements of the related standards and codes is critical to ensure the safety and economy of venting. Definitely, the initial pressure of venting was determined, a feasible venting method was selected, the venting time was calculated and its impact on the environment was evaluated through in-depth analysis of the China Myanmar Natural Gas Pipeline. Additionally, the practice of venting the China Myanmar main pipeline was discussed to provide important practical basis and technical support for reasonably organizing the maintenance and construction of gas pipelines and improving the decision-making level of gas production scheduling.