Abstract: The gas leakage of one buried natural gas pipeline laid in parallel into the air, which results in explosion, maycause the other adjacent target pipeline to fail. In order to study the dynamic response of the target pipeline, a method fordefining the methane-air mixed gas with the non-linear finite element program LS-DYNA was established, the stress anddisplacement changes of the target pipeline under the action of the explosion of hemispherical gas cloud were studied bynumerical simulation, and quantitative analysis was carried out to the six influencing factors including pipe spacing, burieddepth, the wall thickness, diameter and operating pressure of target pipe, and the radius of gas cloud. The results show that, compared with TNT equivalent method and TNO multi-energy method, this method is more accurate in simulating near-fieldexplosions of gas cloud, the maximum equivalent Mises stress of the target pipeline is about 548 MPa when the pipelineis under the action of a flammable gas cloud with a radius of 21m and then yield failure will occur to the pipeline, radialdisplacement happens to the points on the cross-section of target pipeline and the entire pipe sinks, and the parallel pipespacing, buried depth and the radius of leaked gas cloud have a significant effect on the Mises peak stress of target pipeline.Besides, the research results could provide reference for optimization of the risk prevention and control plan of pipelineduring its design and operation.