Abstract: China-Russia Eastern Gas Pipeline has been in the operation stage after commissioning, however, the high steel grade, large diameter, high pressure and large transportation capacity, as well as the cold frozen zone along the pipeline, all pose great challenges to the operation of the pipeline, such as enormous uncertainty, high risks, difficulty in maintenance and security, etc. The problems that may exist in the pipeline technology were elaborated, including optimal operation of the pipeline network, peak shaving in winter, prevention and control of ice blockage, venting and recovery, etc. In the aspect of integrity management, the pipeline was facing problems like in-line inspection of large-diameter pipeline and evaluation of safety status of high-grade steel pipeline. In terms of line risk control, there would be problems such as gas pipeline leakage and safety status monitoring, corrosion, prevention and control of frost heaving and thawing settlement, etc. As for maintenance and repair, a series of technical problems represented by cutting, demagnetization and repair of D 1 422 mm pipeline needed to be solved. The status of related technologies in China and abroad were summarized and technical solutions for the problems were proposed. In addition, some of the technological achievements that have been made in China-Russia Eastern Gas Pipeline were summarized to provide reference for the construction and operation of oil and gas pipeline in the future.