Abstract: China-Russia Eastern Gas Pipeline Project is a major strategic project that is attached with great importance and personally promoted by both of the top leaders of China and Russia, and is considered to be another significant outcome in strengthening the comprehensive energy cooperation partnership between the two countries and deepening the comprehensive strategic cooperation partnership, as well as a major project serving the Belt and Road Initiative and constructing China's four major energy transportation channels. Major achievements made by PetroChina in equipment localization in recent years were summarized, including high-strength line pipes, natural gas power-driven compressor units, oil transfer pump sets, key valves and actuators, flow meters, etc. The latest localization progress in the application of key equipment in China-Russia Eastern Gas Pipeline was introduced, such as 20 MW level power-driven centrifugal compressor units with one-key start-stop function, complete set of SCADA software and hardware for the core control system of pipeline that satisfies the information safety requirements, 56 in (1 in=2.54 cm) Class900 all-welded ball valves and associated electric, pneumatic and hydraulic actuators, 24 in Class900 safety shut-off valves and working regulators in the main line pressure regulating device, etc. The independence and controllability of the key equipment can ensure the national energy security, promote the development of national equipment manufacturing industry, and facilitate the cost reduction and efficiency increase of pipeline operating enterprises.