Abstract: With the outbreak of the epidemic of COVID-19, traffic control, setting of check posts and other control measures have been implemented and posed challenges to the routine inspection of the pipeline. Regarding the issue that pipeline inspection personnel cannot complete the on-site inspection and maintenance under epidemic prevention and control situation, the space-air-ground integrated pipeline intelligent perception technology system was proposed through analyzing the deficiencies of the existing pipeline perception technology. According to the principles of comprehensive perception, unmanned perception, real-time accurate perception and full life cycle perception, the technical route integrating artificial intelligence technology and pipeline perception technology was established. The intelligent interpretation method for satellite remote perception images of pipelines at space level, the unmanned aerial vehicle intelligent inspection method based on automatic airport in air, as well as the intelligent video method for key pipeline areas aboveground and the comprehensive intelligent perception method of underground optical fibers at ground level were designed. The field application of unmanned aerial vehicle(UAV) intelligent inspection technology based on automatic airport was explored. Field tests and applications show that the unmanned aerial vehicle intelligent inspection system based on automatic airport enables the automatic take-off, landing, charging and other operations without the human participation, and the operations following the set inspection path and inspection time. Besides, it can intelligently recognize threat events such as mechanical excavation and personnel gathering. During the epidemic of COVID-19, the UAV flew for more than 80 sorties and recognized more than 20 threats. This shows that it can provide strong technical support for pipeline inspection personnel to master the safety status of pipelines.