Abstract: The anti-surge and load distribution control of compressor set has always been a difficulty that restricts its stable and efficient operation. In order to solve this problem, the anti-surge control of compressor set is carried out by means of the combined method of PI control response, step response, safety response and limit control, and the performance control and load balancing control of compressor set are realized by controlling its inlet/outlet pressure and flow rate, decoupling and balance. And this method was applied to the compressor control system and station control system of the Gaizhou Compressor Station. It is shown that the pressure control of the inlet manifold of the compressor set is stable with small fluctuation and the control effect is remarkable. By virtue of this method, the control on the compressor set of compressor station is safer, more stable and energy-saving and can reach a higher degree of automation, which is beneficial to the safe and stable operation of the Gaizhou Compressor Station.