Abstract: In order to solve the problem of excessive noise in the pipeline of centrifugal compressor at compressor stations, the noise level and noise source of compressor and its pipeline were determined by combining noise measurement, spectrum analysis and vibration measurement. One certain centrifugal compressor set was taken as the research object in this paper. It is shown from the noise measurement that the sound pressure level before and after the valve of centrifugal compressor is the highest and it is up to 100 dB. It is indicated from the spectrum analysis that the sound pressure level in the pipeline of centrifugal compressor is the highest at the vibration frequency of 90 Hz and 1 000–1 400 Hz. It is revealed by carrying out vibration measurement at different positions of the compressor pipeline that peak voltage occurs when the vibration frequency is 90 Hz and 1 250 Hz. The noise corresponding to 90 Hz is caused by the excitation which is induced by the non-coincidence between the center of form and the center of mass in the process of compressor processing, while the noise corresponding to 1 250 Hz is caused by the air flow excitation at the compressor outlet and the air flow excitation generated by air flowing through the valve. Then, the noise generated by fluid flowing through the valve was calculated by means of computational fluid dynamics (CFD) method. It is concluded that the noise at the valve is a kind of broadband noise. Finally, based on the noise source at the valve, a noise reduction method was proposed so as to provide the reference for the smooth operation of centrifugal compressors.