Abstract: As the important technologies for studying hydrates in different scales, differential scanning calorimeter (DSC) and nuclear magnetic resonance (NMR) spectrometer and its derivative magnetic resonance imaging (MRI) technology can be used to plot the heat flow curve in the process of hydrate nucleation, growth and decomposition, identify the structural information and provide the multi-phase state characterization. And they are widely concerned by domestic and foreign scholars. In this paper, the application status of these three methods in hydrate researches was described, and the research progress of DSC macroscopic experimental method under constant pressure & variable temperature and constant pressure & constant temperature in the aspects of hydrate thermodynamics and dynamics was introduced. Then, the study results on the microscopic visualization of MRI during the phase transition of hydrate were summarized, and the application situations of NMR to the structural identification of hydrate and the information acquisition of mixed gas hydrate in the molecular scale (e.g. guest molecular composition, cave occupancy and hydrate number) were overviewed. Finally, in view of the advantages, disadvantages and characteristics of three methods, it was proposed to combine DSC and NMR together to systematically research the generation and decomposition process of hydrate in multi-scale.