Abstract: In order to study the leakage location technique for gas pipelines, a mathematical model of gas pipeline was established based on Runge-Kutta method. By virtue of this model, the leakage of gas pipeline was experimentally simulated based on the test system and the positions of leaking points were computed. Then, the location data was compared with the traditional infrasonic location data to verify the accuracy of the pipeline leakage detection and location technology based on Runge-Kutta method. The simulation tests show that by using the leakage detection and location technique based on Runge- Kutta method, the pipeline leakage can be detected quickly and simply, and its location accuracy can be improved from the 3-10 m of infrasonic detection to 0.5-4 m at the flow rate of 210-400 L/min. In conclusion, the pipeline leakage detection technique based on Runge-Kutta method is more advanced than the traditional infrasonic detection technique, and its detection and location accuracy is improved. In the future, this technique shall be improved and popularized.