Abstract: Along Lanzhou-Chengdu Crude Oil Pipeline, the geological conditions are complex with various geological hazards, which brings about serious potential hazards to the safety of pipeline engineering and people's life and property. In this paper, a risk assessment model and evaluation index system of regional pipeline geological disaster were established based on GIS technology to cope with the hazards of various geological disasters. Then, the risk of the geological disasters along the pipeline was divided into five grades, i.e., highest risk, higher risk, moderate risk, lower risk and lowest risk. Finally, the risk of the geological disasters along Lanzhou-Chengdu Crude Oil Pipeline was evaluated, and the pipeline was divided into fifty-three risk sections of geologic disaster according to the zoning results of geological hazard risk assessment. The evaluation results are consistent with the actual situations of Lanzhou-Chengdu Crude Oil Pipeline. The research results play an important auxiliary role in the prevention and treatment of geological hazards, and also provide a reference for the risk assessment on the geological disasters along other pipelines.