Abstract: In the periphery of long-distance oil and gas pipelines, there are many mining sites that are inconsistent with the Law of the People's Republic of China on the protection of petroleum and natural gas pipelines. And conventionally these mining sites are shut down or the route of the pipeline is changed. In some specific cases, however, the above mentioned methods are uneconomical. In this paper, the damping laws of blasting vibration for different relative locations between vibration source and pipeline were obtained based on China-Myanmar oil and gas pipeline, combined with the mining blasting vibration test, simulation test on the vibration damping of field blasting and non-linear regression calculation which were carried out by Jiahua Cement Plant of Kunming Steel. Based on this, it was put forward that the damage of blasting vibration on pipelines can be eliminated by taking technical measures correspondingly when the distance between the large-and medium-sized mining area and the long-distance pipeline doesn't satisfy the requirements of Law of the People's Republic of China on the protection of petroleum and natural gas pipelines. The research results can be used as the reference for the safety assessment of similar long-distance pipeline engineering.