Abstract: Recently, the key electrical equipments (e.g. frequency converter, synchronous motor and centrifugal compressors) in compressor stations of long-distance natural gas pipelines are increasingly supplied by a variety of new manufactures and are diversified in brands, so the control on the integration between different parts of electric drive compressor sets is more and more difficult. In this paper, systematic analysis, theoretical derivation and data statistics were applied to deal with the problems that often occur during the debugging and integration of control system. The structural principles of the control system of electric drive compressor set were illustrated. Then, the factors that affect the main operation parameter of compressors and motors were analyzed. And accordingly the reliable solution was prepared as follows. First, it is necessary to limit the current of the frequency converter and to regulate the load of the compressor. Second, it is necessary to automatically identify whether auxiliary facilities satisfy the requirement and check the time systematically at the designated time. This solution is well applied in the compressor stations of West-to-East Gas Pipeline. As a result, overload control, one key start and clock synchronization of electric drive compressor sets are realized. It is favorable for operation management and inspection & maintenance optimization of compressor sets and ensures high-efficiency flexible operation of natural gas pipeline systems. The research results are applicable to the subsequent debugging of compressors.