Abstract: Chemical pour point depressant is an important modification means to reduce the pour point and viscosity of waxy crude oil, and it has always been the focus of domestic and foreign scholars. Great progress has been made based on the emergence of novel chemical pour point depressants in recent years. In this paper, existing novel chemical pour point depressants at home and abroad and their preparation methods were reviewed, and the technologies for evaluating the modification effects of novel chemical pour point depressants on waxy crude oil were listed. Then, modification mechanisms and influential factors of novel chemical pour point depressants were illustrated. Finally, the research directions of novel chemical pour point depressants were proposed. It is necessary to unify the researches from three aspects (i.e., apparent, mesoscopic and microscopic) and clarify the modification mechanisms of novel chemical pour point depressants to improve their applicability. And it shall be combined with the researches on low-temperature transportation of waxy crude oil to reveal the low-temperature flowing laws of modified crude oil.