Abstract: There is a certain amount of H₂O, HCl and H₂S in liquefied petroleum gas (LPG), so wet H₂S environment can be formed at the dew point temperature. And in the wet H₂S environment, the body of tank can be easily corroded and cracked with huge danger. In this paper, the 400 m³ LPG spherical tank in South China was taken as the study target to simulate the hazard and influential area of LPG spherical tank leakage by setting the diameter of leakage hole at 50 mm, 100 mm and 150 mm by PHAST accident consequence simulation software. It is shown that corresponding to three leakage hole diameters, the maximum diffusion distance of vaporous cloud is 16.0 m, 29.5 m and 42.0 m, the maximum influential distance of jet fire is 20.0 m, 37.5 m and 53.5 m, the maximum influential distance of flash fire is 16.8 m, 31.8 m and 46.0 m, and the influential distance of vaporous cloud explosion is 462.0 m. The simulated hazard and influential area of leakage accidents provide the reference for the future establishment of different emergency schemes in different leakage zones.