Abstract: Compressor station is essential to long-distance gas pipelines, so it is crucial to ensure smooth operation of compressors and carry out routine maintenance seriously. In this paper, the software YSJ_YXYH for the operating maintenance of centrifugal compressors was developed based on the characteristic curves of centrifugal compressors. This software is divided into two parts, i.e., performance testing and energy consumption testing. It can simulate the operating parameters of compressors under the certain working conditions so as to put forward the reference opinions for adjusting the operating conditions of compressors. And it can simulate the operating costs of the compressor stations under the certain working conditions so as to provide the optimal energy consumption of compressors while they can operate efficiently, and realize operating maintenance of compressors. The performance of this software was verified by taking the historical data of a domestic compressor station as the example. The operation parameters and operation costs of compressors under the certain working conditions were calculated using YSJ_YXYH and SPS respectively and then compared with the actual operation values. It is shown that the calculation results of YSJ_YXYH is much closer to the actual operation values. The optimal energy consumption of the compressor station was worked out by YSJ_YXYH. It is confirmed that the efficiency of the compressor in this station is at high-efficiency zone, and its energy consumption is much better than the actual value. Finally, some suggestions which were proposed for the actual operation of this compressor station by YSJ_YXYH can provide effectively technical support for the safe and smooth operation of compressors in gas stations.