Abstract: With the increasing promotion and application of pipeline integrity management system(PIS), its data bulk and user visits are growing day by day. However, the database performance is now one of the bottlenecks restricting the system's performance improvement. In order to improve the performance of the pipeline integrity management system, shorten system response time and save network bandwidth resources, a set of database optimization strategies based on index, efficient SQL, stored procedure algorithm and materialized view were proposed by taking into account the high concurrency, large data bulk and complex business logic of the pipeline integrity management system. Practical application results show that the database optimization strategy increases the operating efficiency of the pipeline integrity management system by 60% and provides effective technical support for the data maintenance and management of PetroChina's pipeline integrity management system.