Abstract: In order to satisfy the demands for computer performance and information security in digital design of long-distance pipeline, this paper presents a desktop cloud solution based on GPU virtualization through study of desktop virtualization technology and its working principle, and in combination with the characteristics of digital design. With the virtualization technology, the user data, application and desktop operating system can be isolated from the physical client using the layered/coupled principle, and then be stored in the data center. The desktop is taken as a service to be provided to the design user by on-demand. The practical application shows that the desktop cloud technology based on 3D design meets the need of digital design and improves asset utilization rate from about 25% to 85%. In addition, it ensures the security of data without the data in the client. The technology has been successfully applied in the design of long-distance pipeline for the first time, providing reference for similar projects in the future.