Abstract: To address the abnormal vibration of compressors in high-throughput stations, a compressor station was taken as an example for analysis. The air column natural frequency was calculated, verifying the possibility that disturbance may stimulate acoustic resonance in pipeline, and revealing the fundamental cause of vibration. The finite element analysis software Fluent was used to analyze the fluid flow state, which explicated the disturbance source. The ANSYS was used to analyze static stress and thereby diagnose the response to pressure impulse of the centrifugal compressor outlet. Then, dynamic stress was analyzed to identify the sensitive frequency of pipes, revealing a deficiency that structure analysis applied in engineering can not fully reflect why vibration occurs in pipeline. The pipeline structure was optimized, and the solution to the acoustic resonance was discussed. All these methods are adopted to avoid the damage caused by pipeline vibration during operation and ensure the safety of main power equipment and the pipeline.