Abstract: To optimize the atomized adding process of gas drag reduction additive (DRA), software simulation can be used to assess performance of the DRA if it is not possible to verify processes in simulated pipeline section in laboratory due to restricted conditions. In addition, such software can also be used to determine the susceptibility of DRA performance to influencing factors. The results show that deposition concentration of DRA drops is most sensitive to changes in atomizing differential pressure. Furthermore, spraying angle and pipe diameter present certain impacts to deposition concentration - when the spraying angle is large, the deposition concentration is more sensitive to changes in pipeline diameter; when the pipeline diameter is large, the deposition concentration is more sensitive to changes in spraying angles. Relevant simulation results may provide necessary theoretical guidance for on-site application of gas DRA.