Abstract: Cable-stayed aerial crossings of oil and gas pipelines are frequently used for crossover of rivers in canyon zones. To solve problems related to wind vibration stability, pigging vibration, cable tensile balancing and pipe bridge tower rigidity in Beipanjiang Cable-Stayed Aerial Crossing Project of Myanmar-China Oil & Gas Pipeline, wind-tunnel test and finite-element numerical simulations are performed for the cable-stayed aerial crossing and specific sections. Through stepped iteration, proper tensile strengths of cables for cable-stayed aerial crossing with different spans are determined. Combination of counterbalance weight and support abutment is deployed to balance the tensile strength on cables. Through wind-tunnel tests of the entire bride and specific sections, wind vibration parameters required by the structure are determined. Moreover, wind resistance and structural reliability of the crossing are verified. Based on the impacts of gangway board to wind safety, boards with higher rates of wind penetration are deployed. Through comprehensive assessments, bridge tower composed by steel pipes and concrete is taken for construction of the bridge tower with three pipelines deployed vertically. Therefore, wind safety of the structure is guaranteed. In addition, structural vibration and balancing of cable tensile strengths under different conditions are tacked satisfactorily.