Abstract: As to cooling of high-power variable-frequency electric-driven compressor, key equipment for cooling water is selected in consideration of wind, sand, water quality, temperature and other factors. For the process line flow in the cooling tower area, pipeline connection in series and parallel is proposed considering the operation of cooling tower under extreme temperature. Equipment configuration of cooling water pump room along the 2nd West-to-East Gas Pipeline is improved to reserve enough space for control and auxiliary equipment. In general layout, combining each unit location in stations, the line is simplified and the cooling water functional areas are optimized. For water quality, water softener is used in the West-to-East Gas Pipeline project for the first time to conduct softener operation for cooling tower spray water, in order to avoid the coiler corrosion and scaling. In view of the outside pipeline network of the cooling water system, valve pit discharge, antifreezing, overhauling and noise reduction measures are improved. According to the process, the optimal flow allocation of motor and inverter is proposed. By hydraulic analysis of the cooling water system, simulating the fluid dynamic cycle, and calculating the pump lift, pressure loss and lowest point pressure, the safe operation of the pump is guaranteed.