Abstract: There is a controversy in the valve selection, installation position, setting values and other aspects on the long-distance pipeline engineering design. The relevant standards and specifications for safety valves of long-distance pipelines used commonly in China and aboard are concluded, and the selection, installation position, and pressure setting of safety valves in gas stations are analyzed, providing an optimized scheme of safety valve configuration under the design of gas pipeline engineering. Meanwhile, the series connection of safety shut-off valves and pressure regulating valve is recommended for pressure protection, and the safety valve installed downstream of the pressure regulating valve is removed. And it is pointed out that regulations on regulating pressure of safety valves in GB 50251-2003 should be revised since they don't consider the dynamic characteristics of the safety valve in discharge process.