Abstract: In order to reduce the impact of waste spontaneous combustion, subsidence and corrosion on pipeline when it crosses large landfills and to ensure the safety of the crossing pipeline, in this paper, the root of the spontaneous combustion is analyzed, and based on exploration data and the theory and experience of urban landfill treatment industry, models are established to calculate the foundation settlement and degradation settlement data of dump. Moreover, the pipeline stress is also comprehensively analyzed to determine the solution of pipeline deformation. According to the requirements for pipeline anticorrosion technology, composition testing data of garbage are analyzed, the corrosion level is determined, and dual protective measures (corrosion control and cathodic protection) are set up. Operation and monitoring data of pipeline for many years show that this crossing scheme and the protective measures are reasonable and effective, there is no spontaneous combustion in the crossing spot and the settlement and corrosion are under the control. Therefore, it can provide suggestions and references for the scheme selection, the reduction of waste combustion, the influence of settlement and corrosion on pipeline, as well as the aspects of the determination of treatment scheme of crossing projects of similar pipelines in the future.