Abstract: The reliability-based design and assessment (RBDA) method is the prospect of natural gas pipeline design. It is studied intensively by domestic and overseas academic communities. According to the theory involved in RBDA, analysis procedure of pipeline reliability is investigated, universal algorithm of limit state equation of Monte-Carol simulation is provided, and the calculation software framework for pipeline reliability is established. Taking the yield and fracture limit state function of zero defect pipe provided in Appendix O of CSA Z662 as an example, calculation of reliability and sensitivity analysis of parameters of an actual gas pipeline are implemented. Finally, based on the analysis results, feasible suggestions for the pipeline design and management are proposed. The computational method proposed separates the equation and simulation calculation, which is suitable to list more equations in the computing framework, so that a comprehensive analysis can be made for pipeline reliability.