Abstract: CO₂ pipeline transportation is an important link in Carbon Capture, Utilization and Storage (CCUS) technology. Meaningful CO₂ pipelines with large transportation distance and capacity are still a blank in China. According to physical characteristics of CO₂ and the construction experience of CO₂ pipelines abroad, various aspects of engineering design for domestic CO₂ pipelines are discussed in depth, such as gas composition requirements at gas source, selection and control of the transportation phase, pipeline route selection, design principles of valve chambers, area classification, coating selection, sealing performance of equipment materials, pipe performance and other security measures, and practical measures are proposed accordingly. It is pointed out that it is urgent to establish standards on the design, construction and operation of CO₂ pipelines suitable for China. The research is of great significance for promoting the development of CO₂ pipeline projects and CCUS technology in China.