Abstract: According to the problem of cathodic protection interference in a pipeline inland, detection analysis is carried out to understand the characteristics of the cathodic protection interference. Based on the parameters of the buried pipeline and the runing parameters of the cathodic protection system, numerical simulation analysis on the interference field is finished, and the result shows that the spot data cannot fully reflect the distribution of interference potential. Close Interval Potential Survey (CIPS) is needed during the detection of cathodic protection interference in the field, and numerical simulation technology can be used in assistant analysis if necessary. In order to predict the effect of the relevant improvement scheme, pre-evaluation of the scheme is carried out by means of the numerical simulation. The results show that this scheme can eliminate the influence of cathodic protection interference here in the pipeline and its reasonability is discussed in this paper. The way of using numerical simulation to analyze cathodic protection interference on pipeline can provide a reference to the troubleshooting similar construction problems.