Abstract: In order to find out the deformation pattern of buried pipeline in reclaimed soft foundation with uneven settlement, based on geological survey data of Tangshan Caofeidian reclaimed area, subsidence value in the reclaimed foundation is calculated and predicted according to the principle of consolidated compression, settlement pattern of reclaimed soft foundation is figured out, and sedimentation correction factor is used to correct the foundation settlement of highway segment. By setting multi-group quantities of relative foundation settlement as the boundary condition of pipeline deformation, the interaction between pipeline and soil of buried pipeline is simulated by using equivalent spring, stress values on buried pipeline under various deformations are calculated with finite element method. The results show that the road-cross pipeline in Caofeidian reclaimed soft foundation would not break during the 50 years of operation.