Abstract: The operation and maintenance of equipment affect the economy and reliability of the equipment, thus scientific analyzing tools are needed to plan maintenance work in order to reduce the maintenance cost and ensure the reliability of equipment. A new layered FMECA method is proposed for equipment operation and maintenance stage, which combines the function method and element method in traditional FMECA method to conduct the failure mode analysis according to function subsystem and parts, and make the operation and maintenance suggestions more specific. Taking the operation and maintenance of certain type of gas turbine inlet system in gas booster station driving as an example, FMECA analysis has been conducted to provide suggestions in equipment maintenance. During the analysis with FMECA method, its software management system has been developed to assist technicians in regulating analytical progress, reducing analytical workload, and the analytical results conform with the operation and maintenance staffs' experience, verifying the reliability and practicability of this method.