Abstract: In order to identify the flow drag characteristics of gas-solid two-phase flow, the gas-solid two-phase flow in straight and horizontal bent sections of pipelines is numerically simulated using the commercial software CFX which computes fluid dynamics. The software simulation conditions is determined by adopting the Eulerian-Lagrangian method for the choosing of numerical simulation computing model and taking into account the running condition of the simulated objects. Through this simulation, main factors affecting the pressure loss of gas-solid two-phase flow, such as system characteristics and operating conditions of pipeline system, and properties of materials and gas, are discussed, and the continuous phase velocity, pressure distribution characteristics, and particle moving trajectory are analyzed. The pressure field and velocity field distribution of gas-solid two-phase flow, the distribution and trajectory of particle inside pipeline, and the distribution law of system drag and settlement amount of particle under different conditions are derived. In addition, the economic velocity at the lowest energy consumption under certain condition is determined. The research results can provide a reference to the engineering design and theoretical study of gas-solid two-phase flow.