Abstract: Feasibility study on oil and gas pipelines by abrasive jet cutting is conducted through laboratory experiments, to obtain the law for impacts of operating parameters such as pump pressure, nozzle diameter, abrasive concentration, nozzle traverse speed and injection angle on abrasive water jet cutting depth, that is, the abrasive jet cutting depth is proportional to the pump pressure and inversely proportional to the nozzle movement speed and the nozzle diameter, abrasive fraction and injection angle all have optimal values. Genetic algorithms are used to determine and optimize undetermined parameters in the abrasive jet cutting model so as to obtain the cutting depth calculation mode. This model can be used to predict the abrasive jet cutting depth with the maximum error of 16% and minimum error of 1.5%, which complies with engineering requirements.