Abstract: Due to interference from ambient noise, signals acquired by infrasound wave sensors of oil pipeline leak detection and positioning systems are subject to large errors. To this end, hardware based dual-sensor detection methods are used to filter noises of detection signals. It is the specific method that two identical sensors are respectively installed at both ends of the detection pipeline, including one measuring sensor and one compensation sensor, and the output results of the compensation sensor and disturbance variable of the measuring sensor are used to make output results of the detection system not affected by the disturbance variables except for detected parameters so as to achieve signal compensation. Experimental application is made after system optimization, and the error between calculated leak point and set leak point is 123 m and positioning accuracy is relatively high, indicating feasibility of the method.