Abstract: There will be three types of compressor configuration available for electricity-driven compressor stations of in the eastern section pipeline of Second West-to-East Gas Pipeline, that is, 27 MW high-speed direct-connected VF motor scheme (2+1 configuration), 27 MW low-speed motor+gear box scheme (2+1configuration) and 18 MW high-speed direct-connected VF motor scheme (3+1 configuration). For the purpose of determining the drive mode of compressor units, the paper carries out a comparison on the special features of 3 configurations in combination with the characteristics of the Second West-to-East Gas Pipeline and running of compressor stations. Comparison and analysis are made on the compressor property, design capacity and manufacturing period and other comprehensive abilities of suppliers for large power inverters and explosion-proof motors. In view of technological and economical aspects, this paper conducts comparison and selection on drive mode of electric-driven compressor units, and the 18 MW high-speed direct-connected VF motor drive mode is the finally determined unit for electric-driven compressor stations in the eastern section pipeline of Second West-to-East Gas Pipeline.