Abstract: Due to change of gas source and higher gas throughput, the ice block especially in winter is easy to occur for Zhongxian-Wuhan Gas Pipeline after it was reverse transportation process technically reformed. Kinds of natural gas hydrate (NGH) inhibition technology have been compared in this paper. In the light of the NGH formed at lower water dew-point for the 2nd West-to-East Gas Pipeline, compressor stations along the Zhongxian-Wuhan Gas Pipeline commonly have to adopt the heating method and methanol to inhibit NGH. However, these mothods do not meet the requirements of HSE. Based on the research progress in control NGH and running consideration of the pipeline, it is pointed out that inhibiter injection to control hydrate is a best choice in removing ice block, but the optimization for inhibiter is still needed.