Abstract: The Sichuan-East Gas Pipeline connects Puguang Initial Station in Northeast Sichuan and Terminal in Shanghai, And it is extremely difficult to design and construction, Based on the current design ideas and principles of pipeline, the overall design of this pipeline project has been optimized, The processing optimization computation of pipeline network, compressor, storage and peak-shaving have been carried out by Stoner Pipeline Simulator and Pipeline Studio, The process of route selection is made by means of painting line on the map, using Google Earth to validate, and using DEM data and satellite remote sensing technology, Based on the actualities in pipeline operation, all the engineering design of pipe strength and stability, pipeline crossing and spanning, hydrotechnological protection, soil and water conservation have been optimized through the integrated technology, Design optimization on power system is that high-power VSDS distribution design is adopted in compressor stations, substations are installed with 3-layer structure, self-contained power with high reliability is chosen to supply valve chamber, and the technolo-gy of "integer protection lightning" and high frequency grounding grid are utilized in power system, etc, The dynamic control and automatic monitoring on the entire pipeline system are carried out by SCADA system, Skid-mounted metering systems are used in custody transfer metering, And the MSTP/SDH optical communication technology is adopted in communication system.