Abstract: Gas transmission loss of long-distance gas pipeline expresses the difference of inlet gas inventory and pipeline inventory vs outlet gas inventory, which is generally represented with gas transmission loss rate for transmission loss of pipeline.Combined with the management practice in West-to-East Gas Pipeline, how to control the gas transmission loss is discussed from improving accuracy of metedng system, increasing accuracy in pipeline inventory of gas calculation and enhancing management standards in venting operation.To improve the accuracy of metering system needs adopting high-precision metering device, installing on-line analyzer for gas component in large capacity metering station, perfecting running management of metering device, increasing the metering accuracy of self-consumable gas and the calculated veracity of venting volume, enhancing daily monitoring and management on the other side's custody transfer meters and so on; to improve the calculated accuracy of pipeline inventory of gas needs adopting available calculation method for the pipeline inventory of gas, ensuring the calculated accuracy about compressible factor and the veracity of dynamic metering data, rationally partitioning and merging pipeline inventory sections to be calculated to cut down gas venting volume needs strengthening routing inspection on pipeline and stations·decreasing switching frequency and venting for equipment maintenance, perfecting the management on hot tap operation.