Abstract: Based on one dimensional flow of equation of continuity, equation of state, equation of motion and energy equation for gas pipeline, mathematical model is set up and boundary condition is determined.Numerical solving is carried out with fourth-order Runge-Kutta solution and VB program design language is applied to write calculation procedure.Primary parameters for pipeline are designed on the basis of optimization to obtained optimized economic profits for gas pipeline.Calculation case shows that the above-mentioned design method can provide an important technical support to optimal design of long-distance gas pipeline.